This episode Andrew is working out the evidence on depression. He addresses the 500lb elephant around the future of Questioning Medicine, but luckily he doesn't try to lift it. He also makes everyone in the world hate him when he complains of the 70 degree winter he is currently experiencing.
Andrew is by himself and trying to struggle through the harsh Florida winter. The question today is should steroids, more specifically prednisolone, be given to those with alcoholic hepatitis? A quick look at the evidence and even go back to some original research from the 70's! Before you hit play can you guess what the music for this alcoholic podcast is going to be?
In this episode Andrew is joined by a new kid on the block, Dr. Jon Settle. Together they break down the evidence around DDP-4 inhibitors. Do these drugs cause heart failure? How much do they lower A1C? Would they write for them and if so in what patients?
Andrew gets called out by the surrogate marker Marshal after making claims of benefit exclusively from biomarkers.
Joe is back and goes over the top with his first chance to edit a podcast in a long time.
PCSK9 inhibitors are not as Ugly as they seem, Andrew isn't as good without Joe and Joe is...not as good as he once was.
We are trying a new thing, answer a question based on a recent article. In this episode we talk about the use or benefit of knee arthroscopic surgery. Joe talks about the orthopedic two step. Andrew learns of the best treatment for degenerative knee, however he still prefers surgery. Give us feedback and check out the website we are slowly updating www.questioningmedicine.com
Andrew is back to being by himself. When you get out questioned in questioning medicine its time for a podcast update. This episode briefly touches on the granulocyte colony stimulating factor and is this $5000 dollar drug worth the price tag or just an expensive Tylenol?